Gu, TP et al. The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes. Nature 477606–610 (2011).
Wossidlo, M. et al. 5-Hydroxymethylcytosine in the mammalian zygote is linked with epigenetic reprogramming. Nat. Commun. 2241 (2011).
Iqbal, K., Jin, SG, Pfeifer, GP & Szabo, PE Reprogramming of the paternal genome upon fertilization involves genome-wide oxidation of 5-methylcytosine. Proc. Natl Acad. Sci. USA 1083642–3647 (2011).
Hackett, JA et al. Germline DNA demethylation dynamics and imprint erasure through 5-hydroxymethylcytosine. Science 339448–452 (2013).
Dawlaty, MM et al. Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development. Dev. Cell 24310–323 (2013).
Yamaguchi, S., Shen, L., Liu, Y., Sendler, D. & Zhang, Y. Role of Tet1 in erasure of genomic imprinting. Nature 504460–464 (2013).
Yamaguchi, S. et al. Tet1 controls meiosis by regulating meiotic gene expression. Nature 492443–447 (2012).
Inoue, A. & Zhang, Y. Replication-dependent loss of 5-hydroxymethylcytosine in mouse preimplantation embryos. Science 334194 (2011).
Amouroux, R. et al. De novo DNA methylation drives 5hmC accumulation in mouse zygotes. Nat. Cell Biol. 18225–233 (2016).
Hirasawa, R. et al. Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev. 221607–1616 (2008).
Guo, F. et al. Active and passive demethylation of male and female pronuclear DNA in the mammalian zygote. Cell Stem Cell 15447–459 (2014).
Shen, L. et al. Tet3 and DNA replication mediate demethylation of both the maternal and paternal genomes in mouse zygotes. Cell Stem Cell 15459–471 (2014).
Peat, JR et al. Genome-wide bisulfite sequencing in zygotes identifies demethylation targets and maps the contribution of TET3 oxidation. Cell Rep. 91990–2000 (2014).
Nakamura, T. et al. PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos. Nature 486415–419 (2012).
Begemann, M. et al. Maternal variants in NLRP and other maternal effect proteins are associated with multilocus imprinting disturbance in offspring. J. Med. Genes. 55497–504 (2018).
Hui, P., Buza, N., Murphy, KM & Ronnett, BM Hydatidiform moles: genetic basis and precision diagnosis. Annu. Rev. Pathol. 12449–485 (2017).
Docherty, LE et al. Mutations in NLRP5 are associated with reproductive waste and multilocus imprinting disorders in humans. Nat. Commun. 68086 (2015).
Murdoch, S. et al. Mutations in NALP7 cause recurrent hydatidiform moles and reproductive wastage in humans. Nat. Genes. 38300–302 (2006).
Amousahi, M., Sunde, L. & Lykke-Hartmann, K. The pivotal roles of the NOD-like receptors with a PYD domain, NLRPs, in oocytes and early embryo development. Biol. Reprod. 101284–296 (2019).
Qin, D. et al. The subcortical maternal complex protein Nlrp4f is involved in cytoplasmic lattice formation and organelle distribution. Development 146dev183616 (2019).
Tong, ZB et al. Mater, a maternal effect gene required for early embryonic development in mice. Nat. Genes. 26267–268 (2000).
Mahadevan, S. et al. Maternally expressed NLRP2 links the subcortical maternal complex (SCMC) to fertility, embryogenesis and epigenetic reprogramming. Sci. Rep. 744667 (2017).
Schutsky, EK et al. Nondestructive, base-resolution sequencing of 5-hydroxymethylcytosine using a DNA deaminase. Nat. Biotechnol. https://doi.org/10.1038/nbt.4204 (2018).
Guo, F. et al. Single-cell multi-omics sequencing of mouse early embryos and embryonic stem cells. Cell Res. 27967–988 (2017).
Hackett, JA, Zylicz, JJ & Surani, MA Parallel mechanisms of epigenetic reprogramming in the germline. Gene Trends. 28164–174 (2012).
Seisenberger, S., Peat, JR & Reik, W. Conceptual links between DNA methylation reprogramming in the early embryo and primordial germ cells. Curr. Opin. Cell Biol. 25281–288 (2013).
Seisenberger, S. et al. The dynamics of genome-wide DNA methylation reprogramming in mouse primordial germ cells. Mol. Cell 48849–862 (2012).
Li, X. et al. A maternal-zygotic effect gene, Zfp57, maintains both maternal and paternal imprints. Dev. Cell 15547–557 (2008).
Strogantsev, R. et al. Allele-specific binding of ZFP57 in the epigenetic regulation of imprinted and non-imprinted monoallelic expression. Genome Biol. 16112 (2015).
Au Yeung, WK et al. Histone H3K9 methyltransferase G9a in oocytes is essential for preimplantation development but dispensable for CG methylation protection. Cell Rep. 27282–293 and 284 (2019).
Zeng, TB, Han, L., Pierce, N., Pfeifer, GP & Szabo, PE EHMT2 and SETDB1 protect the maternal pronucleus from 5mC oxidation. Proc. Natl Acad. Sci. USA 11610834–10841 (2019).
Dai, HQ et al. TET-mediated DNA demethylation controls gastrulation by regulating Lefty-Nodal signaling. Nature 538528–532 (2016).
Guo, H. et al. DNA methylation and chromatin accessibility profiling of mouse and human fetal germ cells. Cell Res. 27165–183 (2017).
Shahbazi, MN, Siggia, ED & Zernicka-Goetz, M. Self-organization of stem cells into embryos: a window on early mammalian development. Science 364948–951 (2019).
Yan, R. et al. Decoding dynamic epigenetic landscapes in human oocytes using single-cell multi-omics sequencing. Cell Stem Cell 281641–1656.e7 (2021).
Gu, C., Liu, S., Wu, Q., Zhang, L. & Guo, F. Integrative single-cell analysis of transcriptome, DNA methylome and chromatin accessibility in mouse oocytes. Cell Res. 29110–123 (2019).
Wu, SC & Zhang, Y. Active DNA demethylation: many roads lead to Rome. Nat. Rev. Mol. Cell Biol. 11607–620 (2010).
Barlow, DP Genomic imprinting: a mammalian epigenetic discovery model. Annu. Rev. Genes. 45379–403 (2011).
Hackett, JA & Surani, MA DNA methylation dynamics during the mammalian life cycle. Philos. Trans. R. Soc. London. B Biol. Sci. 36820110328 (2013).
Szabo, PE, Hubner, K., Scholer, H. & Mann, JR Allele-specific expression of imprinted genes in mouse migratory primordial germ cells. Mech. Dev. 115157–160 (2002).
Smallwood, SA et al. Single-cell genome-wide bisulfite sequencing for assessing epigenetic heterogeneity. Nat. Methods 11817–820 (2014).
Picelli, S. et al. Full-length RNA-seq from single cells using Smart-seq2. Nat. Protoc. 9171–181 (2014).
Shen, Y. et al. A map of the cis-regulatory sequences in the mouse genome. Nature 488116–120 (2012).